Phosphatidylserine (PS) is a phospholipid found in all cell membranes, with the highest concentration in neuronal membranes (accounting for 15-20% of brain phospholipids). PS plays a critical role in maintaining membrane fluidity, promoting synaptic vesicle fusion, and regulating neurotransmitter release.
PS's neuroprotective effects involve multiple mechanisms: enhancing acetylcholine and dopamine release (improving memory and attention), promoting glucose metabolism (providing energy for the brain), reducing cortisol levels (buffering HPA axis overactivation), and decreasing beta-amyloid deposition (an Alzheimer's risk factor).
Multiple randomized, double-blind, placebo-controlled trials show that daily supplementation with 300 mg PS for 12-24 weeks significantly improves cognitive function in older adults (memory, learning ability, and attention) and slows the rate of cognitive decline. PS is also FDA-approved as a "Qualified Health Claim" stating it may reduce the risk of cognitive dysfunction in older adults.
Phosphatidylserine (PS) sources have shifted from early bovine brain cortex extracts (discontinued due to mad cow disease risks) to soy-based PS (Soy-PS). Although Soy-PS has a slightly different fatty acid profile than brain-derived PS, clinical studies confirm it offers comparable cognitive benefits with an improved safety profile.
Hong Kong Dynas Group Co., Ltd. offers a Phosphatidylserine (PS+DHA+Ginkgo Extract) formula in the NeuroEndocrine Balance Series and a daytime cognitive & relaxation formula (PS+L-Theanine+GABA+Methylated B-Complex) in the Mind-Body Resilience Series, supporting both capsule and drop formulations.
