Sirtuins are a family of NAD+-dependent deacetylases that play central roles in energy metabolism, DNA repair, inflammation regulation, and lifespan control. Humans have 7 sirtuins (SIRT1–7), with SIRT1 being the most extensively studied and often referred to as the "longevity protein."
SIRT1 activity strictly depends on NAD+ levels, as NAD+ is an essential substrate for SIRT1 catalysis. Consequently, declining NAD+—a hallmark of aging—directly reduces SIRT1 activity, impairing DNA repair, mitochondrial function, and metabolic regulation. Restoring NAD+ levels is a prerequisite for recovering SIRT1 activity.
Resveratrol is a polyphenol found in grape skins, blueberries, and Japanese knotweed. It acts as a natural allosteric activator of SIRT1. Research from Harvard's David Sinclair team shows that resveratrol enhances SIRT1 deacetylase activity on substrate proteins (such as PGC-1α, p53, and NF-κB) by allosterically modulating its substrate-binding pocket.
The combination of resveratrol and NMN creates a complete anti-aging pathway: NMN boosts NAD+ levels (providing the substrate for SIRT1 reactions) → Resveratrol activates SIRT1 (enhancing deacetylation efficiency) → SIRT1 deacetylates PGC-1α (promoting mitochondrial biogenesis), p53 (reducing apoptosis), and NF-κB (suppressing inflammation). This "NAD+ boost +SIRT1 activation" combo has become the standard design for functional medicine anti-aging products.
Dynas Group Co., Ltd. Hong Kong offers specialized NAD+ boosting formulations (NMN/NR + Resveratrol + TMG) in the Energy & Mitochondrial Series, available as capsules, powders, or sublingual tablets with customizable options. The formula is designed around a complete anti-aging pathway logic: "NAD+ precursor supplementation +SIRT1 activation + methyl support."
